Abstract
The effect of directional stretching of the substratum on cell orientation was investigated using Earle's L strain fibroblasts. An apparatus was constructed that caused a silicon rubber substratum to undergo periodic elongation and recoil at 15 sec intervals. This substratum was contained within a flask that also held a control (static) substratum of the same material. Examination of the pattern of cells by scanning electron microscopy (SEM), made after 18–24 h incubation, showed a highly significant preponderance over the controls of cells on the stretching substrata arranged with their long axis at right angles to the direction of stretching. The observation is interpreted as an avoidance reaction to stretching based on the cells' adhesion by linear focal contacts, which run parallel to the long axis of the cells, and which are associated with microfilaments.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
