Reorganization of trigeminal primary afferents following neonatal infraorbital nerve section in hamster

Abstract

The infraorbital nerve was sectioned and the ipsilateral whisker follicles were cauterized in hamsters within 12 h of birth. Sixty to ninety days later application of HRP to the proximal stumps of the ipsilateral lingual, inferior alveolar, mylohyoid and auriculotemporal nerves resulted in increased numbers of labeled somata in trigeminal ganglion regions which contain primarily infraorbital cell bodies in normal animals. The labeled central processes of mandibular nerves also occupied portions of the brainstem trigeminal complex normally innervated by infraorbital axons. These findings represent the first anatomical demonstration of trigeminal primary afferent plasticity.