Rentabilidad diagnóstica y complicaciones de la linfadenectomía ampliada frente a la limitada asociada a prostatectomía radical

Abstract

BackgroundLymphadenectomy for prostate cancer (PC) is the most reliable procedure for detecting lymphatic metastases. The optimal extension of this procedure is still a topic of debate. ObjectiveTo analyse the diagnostic performance and complications of extended lymphadenectomy (ELD) and limited lymphadenectomy (LLD) in a series of patients with high-risk PC who underwent radical prostatectomy (RP). Material and methodsA retrospective study was conducted on patients with high d’Amico risk who underwent RP with lymphadenectomy between 1999 and 2014.A comparative analysis was performed of the diagnostic capacity of lymphatic metastases of ELD and LLD and of postoperative complications at 90 days. ResultsNinety-three patients were analysed, 20 (21.5%) and 73 (78.5%) of whom underwent ELD and LLD, respectively. The mean age of the series was 65.26 years (SD, 5.51). The median follow-up was 1.51 (0.61–2.29) years in the ELD group and 5.94 (3.61–9.10) in the LLD group.The median number of nodes obtained was 13 (9–23) in the ELD group compared with 5 (2–8) in the LLD group (p <.001). The percentages of patients with positive nodes in the ELD and LLD groups were 35% and 5.47%, respectively (p <.001).The overall complication rate at 90 days was 35.5% (33 patients). In the ELD group, 12 patients (60%) had complications, compared with 21 patients (28.8%) in the LLD group (p=.016), with no significant differences in severity according to the Clavien scale (p=.73). ConclusionsIn our series, the detection of metastatic nodes was significantly greater with ELD. ELD increases the number of complications, with no differences compared with LLD in severity according to the modified Clavien scale.