Abstract
Chronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified Laminaria japonica polysaccharide (LJP61A) on renal function using an adenine-induced CRF mice model. Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of LJP61A in a dose-dependent manner. Additionally, LJP61A could dramatically reduce weight loss, improve the urine biochemical index, and regulate the electrolyte disturbance of CRF mice. These results suggest that the renal function of adenine-induced CRF mice can be improved by LJP61A, which might be developed into a potential therapeutic agent for CRF patients.
Highlights
Chronic renal failure (CRF) is a type of kidney disease characterized by a slow and progressive decline in renal function leading to irreversible kidney sclerosis and nephron loss [1]
CRF mice were significantly reversed by LJP61A. These results indicated that the physiological state of adenine-induced CRF mice could be enhanced by LJP61A
We found that the fibrosis proliferation in the renal interstitium and brown purine crystal deposition in renal tubules and interstitium were observed in the adenine-induced CRF mice
Summary
Chronic renal failure (CRF) is a type of kidney disease characterized by a slow and progressive decline in renal function leading to irreversible kidney sclerosis and nephron loss [1]. In China, there are 119.5 million CRF patients in 2012, with an overall prevalence of 10.8% [4]. The main therapeutic modalities for end-stage CRF are hemodialysis and kidney transplantation [5]. Patients treated with hemodialysis are reported to have a higher overall risk of developing cancer when compared to the general population [6]. There have been advances in kidney transplantation, limited available sources of kidneys restrict its application [5].
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