Abstract
Renoprotective effect of inhibiting renin-angiotensin-aldosterone system (RAAS) by captopril versus losartan on drug-induced acute kidney injury (AKI)
Highlights
Acute kidney injury (AKI) is a common health problem especially the drug induced acute kidney injury (AKI) is a side or toxic effect during treatment of different medical disorders
All components of the renal renin angiotensin aldosterone system (RAAS) (Renin Angiotensin Aldosterone System) which are produced being completely independent of the RAAS (Renin Angiotensin Aldosterone System) and contribute to the progression of both chronic and acute diseases of kidney [13]
In the current study at two different levels we have to evaluate the renoprotective effect of blocking RAAS (Renin Angiotensin Aldosterone System); by AII receptor blocker (ARB) losartan and by angiotensin converting enzyme inhibitor (ACEI) (Angiotensin converting enzyme inhibitor)
Summary
Acute kidney injury (AKI) is a common health problem especially the drug induced AKI is a side or toxic effect during treatment of different medical disorders. Administration of either captopril or losartan in AKI (acute kidney injury) groups showed significant (P≤0.05) decrease of SBP (Systolic Blood Pressure) as compared to that of untreated AKI group. In SBP (Systolic Blood Pressure) in AKI (acute kidney injury) groups which were treated with captopril or losartan showed no significant difference.
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