Abstract
The aim of the study was to investigate the protective effect of Danhong injection (DHI) on diabetic kidney disease and explore the potential mechanisms. Diabetic kidney disease was induced by unilateral nephrectomy, high-fat diet, and streptozotocin. After DHI administration, the renal function deterioration, 24-hour total urine protein excretion, and elevated serum lipid levels were reversed to some extent, and the renal pathological damage was also ameliorated. The KEGG pathway enrichment analysis demonstrated that the PPARγ signal pathway was significantly upregulated in DH group. And the increased expressions of PPARγ and UCP-1 were confirmed by immunohistochemistry, whereas the p38MAPK was significantly decreased. These data show that DHI could delay the progress of DKD, and the effect might be achieved in part by activating the PPARγ signaling pathway.
Highlights
Diabetic kidney disease (DKD) is one of the diabetic microvascular complications characterized by proteinuria and progressively deterioration of renal function
We examined the serum levels of blood urea nitrogen (BUN), Cr, cystatin C (Cys-C), and 24 h-TP to determine the therapeutic effect of Danhong injection (DHI) for DKD rats
The results confirmed that the PPARγ and uncoupling protein-1 (UCP-1) were significantly decreased in kidneys of DKD rats restored after treatment with DHI
Summary
Diabetic kidney disease (DKD) is one of the diabetic microvascular complications characterized by proteinuria and progressively deterioration of renal function. A variety of treatment strategies still could not completely prevent the progress of DKD into end-stage renal disease (ESRD). Among patients with type 2 diabetes mellitus and stage 4 chronic kidney disease, bardoxolone methyl, a nuclear factor. Liu et al reported that DHI inhibited the development of diabetic retinopathy and nephropathy in diabetic db/db mice [13]. These data suggested that DHI could effectively delay the progress of DKD, but the molecular mechanisms for the renoprotective effects of DHI were still unclear. We established a DKD rat model to explore the renoprotective effect of DHI and investigate the underlying mechanisms
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
