Abstract
Only two publications exist in which actual values for the renal clearance of intact melatonin in man is described. The melatonin clearance values were, however, obtained either after the oral intake of melatonin, or by applying different techniques for the determination of melatonin in urine and plasma. In this study, renal clearance of melatonin was determined during the hours where melatonin concentrations are relatively constant. Melatonin levels in plasma and urine respectively were each determined by three analytical techniques, i.e. the Fraser, NID and WHB methods. The results show renal clearance of melatonin to be under 2 ml/min and that higher values are obtained with analytical techniques which bypass the extraction process.
Highlights
Two publications exist in which actual valuesfo r the renal clearance o f intact melatonin in man is described
O pruim ingsw aardes in hierdie studie is egter gedoen na orale m elatonientoediening en verskillende metodes is gebruik vir die bepaling van melatonien in urien en plasm a onderskeidelik
The results showed the renal clearance of melatonin to be under 2 ml/min and demonstrated that higher values are ob tained with analytical techniques which bypass the extrac tion process
Summary
Viljoen* Departem ent Fisiologie, Universiteit van Pretoria, Posbus 2034, Pretoria, 0001. Slegs twee publikasies bestaan waarin die omvang van die renale opruiming van melatonien in mense beskryf word. Die m elatonienopruimingswaardes is egter verkry na óforale toediening van melatonien ó fd eu r verskillende tegnieke te gebruik vir die bepaling van m elatonien in die plasm a en urien onderskeidelik. In hierdie studie is m elatonienopruim ing bepaal o a r 'n tyd van die dag w anneer die plasm avlakke relatief konstant bly, en is die melatonienvlakke in plasm a en urien elk onderskeidelik m et die Fraser-, NID- en WHB-metodes bepaal. Die resultate toon dat melatonienopruiming onder 2 ml/min is en dat hoër waardes verkry word wanneer van metodes gebruik gemaak word wat die ekstraksieprosedures omseil
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