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Abstract
BackgroundRenalase plays an important role in blood pressure regulation. Obstructive sleep apnea (OSA) is a common respiratory disorder associated with hypertension and cardiovascular complications. The aim of the study was to assess the relationship between sleep apnea and renalase concentration.Material and methodsAdult patients (n = 113) were evaluated for OSA in a sleep laboratory using polysomnography. The respiratory events were scored according to the standards developed by the American Academy of Sleep Medicine. The blood renalase concentration was determined by the ELISA (enzyme-linked immunosorbent assay) test.ResultsOSA (AHI ≥ 5) was diagnosed in 71% (n = 80) of the studied population. Renalase concentration was statistically significantly lower in the group with moderate-to-severe OSA (AHI ≥ 15) compared with the group without OSA (AHI < 5) (139.56 ± 175.72 ng/ml vs. 230.97 ± 240.50 ng/ml, p = 0.042). We have found statistically significant negative correlation between renalase and AHI in hypertensives, but not in normotensives. The statistically significant negative correlation was observed between AHI and renalase in the whole studied group, in males, and in the group of age < 60 years old. There was not such a correlation in females and in the group > 60 years old. Based on the regression model, it was shown that lower renalase concentration, hypertension, higher BMI, and male gender are independently associated with higher AHI.ConclusionsThere is a relationship between the blood renalase concentration and the severity of OSA, which may influence hypertension development in OSA.
Highlights
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of either complete upper airway collapse or partial collapse during sleepSleep Breath (2021) 25:669–675 hypoxemia, sleep fragmentation, nocturnal fluid shift, activation of renin-angiotensin-aldosterone (RAA) system, and endothelial dysfunction may play a role in increase of blood pressure
Based on the regression model, it was shown that lower renalase concentration, hypertension, higher BMI, and male gender are independently associated with higher apnea/hypopnea index (AHI)
There is a relationship between the blood renalase concentration and the severity of OSA, which may influence hypertension development in OSA
Summary
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of either complete upper airway collapse (apneas) or partial collapse (hypopneas) during sleepSleep Breath (2021) 25:669–675 hypoxemia, sleep fragmentation, nocturnal fluid shift, activation of renin-angiotensin-aldosterone (RAA) system, and endothelial dysfunction may play a role in increase of blood pressure. The increased renalase has been reported in patients with arterial hypertension [16] and positively related to blood pressure in clinical studies [18, 19]. The relationship between blood renalase concentration and the intensity of sleep bruxism has been shown [20]. The statistically significant negative correlation was observed between AHI and renalase in the whole studied group, in males, and in the group of age < 60 years old There was not such a correlation in females and in the group > 60 years old. Based on the regression model, it was shown that lower renalase concentration, hypertension, higher BMI, and male gender are independently associated with higher AHI
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