Abstract
BackgroundTo explore the characteristics of diffusion tensor imaging (DTI) and magnetic resonance (MR) imaging in healthy native kidneys.MethodsSeventy-three patients without chronic kidney disease underwent DTI-MRI with spin echo-echo planar (SE-EPI) sequences accompanied by an array spatial sensitivity encoding technique (ASSET). Cortical and medullary mean, axial and radial diffusivity (MD, AD and RD), fractional anisotropy (FA) and primary, secondary and tertiary eigenvalues (λ1, λ2, λ3) were analysed in both kidneys and in different genders.ResultsCortical MD, λ2, λ3, and RD values were higher than corresponding medullary values. The cortical FA value was lower than the medullary FA value. Medullary λ1 and RD values in the left kidney were lower than in the right kidney. Medullary λ2, and λ3 values in women were higher than those in men. Medullary FA values in women were lower than those in men. Medullary FA (r = 0.351, P = 0.002) and λ1 (r = 0.277, P = 0.018) positively correlated with eGFR. Medullary FA (r = −0.25, P = 0.033) negatively correlated with age.ConclusionsRenal water molecular diffusion differences exist in human kidneys and genders. Age and eGFR correlate with medullary FA and primary eigenvalue.
Highlights
To explore the characteristics of diffusion tensor imaging (DTI) and magnetic resonance (MR) imaging in healthy native kidneys
Seventy-three patients without chronic kidney disease underwent DTIMRI with spin echo-echo planar (SE-EPI) sequences accompanied by an array spatial sensitivity encoding technique (ASSET)
Renal water molecular diffusion differences exist in human kidneys and genders
Summary
To explore the characteristics of diffusion tensor imaging (DTI) and magnetic resonance (MR) imaging in healthy native kidneys. Age and eGFR correlate with medullary FA and primary eigenvalue. Diffusion Tensor Imaging in Kidney filtration and reabsorption of water and solutes. Understanding water diffusion in the kidney will help better manage many kidney diseases [1]. Laboratory parameters, such as serum creatinine or estimated glomerular filtration rate (eGFR), are commonly used for providing renal filtration information. These parameters are not very sensitive or specific. They do not provide split renal function or renal tubule reabsorption information. This invasive procedure can have serious complications and is restricted in its clinical application
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