Abstract
In 25 patients in different stages of chronic pyelonephritis the renal clearance of uric acid, osmotically active substances and endogenous creatinine and their mutual relationship were investigated. It was found that the ratioCua/Ccr×100 rises in a hyperbolic relation with the decline of endogenous creatinine clearance. The rise of the ratioCua/Ccr×100 rose in a linear relationship to the fractional excretion of all osmotically active substances (Cosm/Ccr×100). The findings support the idea that osmotic diuresis in the residual nephron is one of the factors conditioning the relative increase of renal uric acid excretion.
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