Abstract
Renal tubulointerstitial lesions were investigated in F344 rats which were treated with 1 mg/kg b.w. of mercuric chloride (HgCl2) one (day 0) and three times (days 0, 2 and 4), and killed at days 2, 4, and 6 and at days 6, 8, 10, and 20, respectively. Mild to moderate necrosis (at day 2) and subsequent regeneration (at day 4) were found in the epithelial cells of the straight portion of the proximal tubules in the cortico-medullary junction. At and after day 6, slight fibrosis with slight mononuclear cell infiltration was observed around the affected and dilated tubules. These mononuclear cells were mainly composed of ED1-, CD8-, and α-SMA-positive cells. The level of TGF-β1 mRNA evaluated by RT-PCR slightly increased, and TGF-β1-immunoreactivity was seen along the brush borders as well as in the basal cytoplasm of the epithelial cells. In comparison with the results of our previous reports in BN rats (J Toxicol Pathol 1998; 11: 241-248, Int J Exp Pathol 1999; 80: 125-132), the nature of renal tubulointerstitial lesions was almost similar but the severity of them was apparently milder in F344 rats.
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