Abstract
Abstract Renal tubular disorders in childhood are rare, but, when present, may produce profound electrolyte and volume disturbances. Children with hereditary tubular dysfunction commonly present in the first year of life with failure to thrive and other non-specific symptoms. Biochemical analysis of both serum and urine, together with clinical history and examination, remain fundamental for their diagnosis, whilst localization of the renal tubular defect to the proximal or distal nephron is necessary for understanding of the underlying pathophysiology and appropriate management. During recent years, important new information concerning diagnosis and treatment of selective tubular disorders has been acquired.
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