Abstract
The histological changes in 46 specimens from 18 renal allografts performed in rabbits presensitized by 5–6 injections of donor kidney homogenate have been analysed semi‐quantitatively. Cytotoxic antibodies against donor leucocytes could be demonstrated in all presensitized rabbits at the time of transplantation. Two of the allografts showed a morphological pattern characteristic of hyperacute rejection, i.e. extensive glomerular micro‐thrombosis and cortical necrosis. Compared with allografts from non‐sensitized recipients, the frequency of proliferative glomerulitis, thrombosis, including glomerular microthrombosis, and necrosis was increased; the frequency of lymphocytic infiltration was about the same. The frequency of morphological alterations was lower in homogenate treated recipients than in allografts from rabbits presensitized by multiple skin grafts from the donor.
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Schedule a callMore From: Acta Pathologica Microbiologica Scandinavica Section A Pathology
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