Abstract
SUMMARY Renal transplantation between two inbred strains of rats which differed strongly at a major histocompatibility locus was performed without immunosupperssive treatment. Eleven percent of 55 allografted animals in the Buffalo (BUF) ➝ Lewis (LEW) combination were alive 180 days after transplantaion. Allografted animals of the BUF ➝ LEW and LEW ➝ BUF strain combinations which died less than 50 days post-transplant demonstrated differing patterns of post-transplant renal function and survival times. When lymphocytes from allografted animals surviving more than 180 days were mixed with lymphocytes from normal animals of the donor strain, marked proliferative activity occurred, demonstrating the immunocompetency of the long lived allografted animals. Prolonged allograft survival may not be attributable 10 tolerance
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