Abstract
Organically synthesized lysinoalanine was fed to weanling rats at levels of 0, 0·025, 0·05, 0·1 and 0·3% in a semi-purified diet. Karyomegalic alterations were observed in the renal tubular cells of all animals fed the lysinoalanine diets for 4 wk, and the high dose level also caused tubular necrosis. Renal lesions were observed also after oral or ip administration of 30 mg lysinoalanine for 7 days, and consisted of dilatation of proximal tubules, necrosis of epithelial cells and karyomegalia, limited almost exclusively to the outer medullary stripe. The administration of relatively small quantities of lysinoalanine produced lesions analogous to those seen in rats fed alkali-treated proteins for much longer periods of time.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
