Abstract
Clinical background C-type natriuretic peptide (CNP) is a 22-amino-acid peptide produced mainly in the endothelium and is a ligand for a guanylyl cyclase-coupled receptor, the NPR-B receptor. Recent studies have revealed that in overt heart failure (HF), the predominant natriuretic peptide (NP) receptor in the kidney is the NPR-B receptor. CNP has a potent cardiac unloading action and reduces blood pressure but has minimal renal actions. Based on our previous knowledge, we altered the amino acid (aa) sequence in the ring structure of CNP and fused a 5 aa sequence from ANP to the Nterminus and a 6 aa sequence from BNP to the C-terminus of CNP. We hypothesized that this novel hybrid peptide ABC-NP would maintain CNP's inherent cardiac unloading characteristics plus gaining renal enhancing properties without hypotensive effects.
Highlights
Horng H Chen*, Alessandro Cataliotti, Fernando L Martin, John A Schirger and John C Burnett Jr
4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S1-info.pdf
Based on our previous knowledge, we altered the amino acid sequence in the ring structure of C-type natriuretic peptide (CNP) and fused a 5 aa sequence from ANP to the Nterminus and a 6 aa sequence from BNP to the C-terminus of CNP. We hypothesized that this novel hybrid peptide ABC-natriuretic peptide (NP) would maintain CNP's inherent cardiac unloading characteristics plus gaining renal enhancing properties without hypotensive effects
Summary
Renal targeted protein therapeutics in experimental overt heart failure with renal dysfunction. Horng H Chen*, Alessandro Cataliotti, Fernando L Martin, John A Schirger and John C Burnett Jr. Address: Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester MN 55902, USA. Published: 11 August 2009 BMC Pharmacology 2009, 9(Suppl 1):P7 doi:10.1186/1471-2210-9-S1-P7. 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S1-info.pdf
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