Abstract
The renal response to saline load has been studied in 15 dogs with experimental liver disease due to common bile duct division. After a saline load in these animals, renal sodium retention occurred which was independent of changes in glomerular filtration rate. The abdominal caval pressure was elevated at this time and may have contributed to intrarenal pressure changes that altered tubular flux of sodium. Sodium retention may occur in experimental liver disease because of (1) hemodynamic factors either impeding tubular flux or causing an abnormal intrarenal distribution of blood flow, (2) decreased glomerular filtration rate, and (3) as a late event, an elevated plasma aldosterone.
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