Abstract
F. has been widely used in infants with BPD but the renal effects of F have not been well evaluated. Ten infants (mean±SD, B.W. 1069±405gms, G.A. 29±2.0 wks, postnatal age 159±62 days, wt. at study 3525±2946gms) with BPD were given two doses of F: lmg and 2mg/kg IV in a 24 hr interval. Urine output (U/0), GFR, FENa, FEK, FECa, serum lytes and Ca were evaluated prior to study and 24 and 48 hrs following the onset of study. Management of BPD and fluid therapy were not altered during the study. This study indicates that in infants with BPD, 1) F sign. increases diuresis, natriuresis, kaliuresis and Ca excretion 2) hypokalemia and hypochloremia occur associated with increased loss of K and Cl in urine 3) serum Na and Ca are normal despite increased urine loss 4) GFR remains unchanged.
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