Abstract
Objective: to define a role of renal reperfusion lesion in the development of renal failure in cancer patients after elimination of longstanding urinary tract occlusion. Subjects and methods. The study covered 26 patients in whom cancer disease was complicated by the development of urinary tract obstruction with evolving renal failure. All the patients received surgical treatment aimed at eliminating urinary tract occlusion. In the early postoperative period, progression of renal dysfunction was seen in all cases. The time course of changes in microcirculation, gas exchange, oxidative-antioxidative balance, and renal function were investigated to study the mechanisms responsible for the development of renal failure after surgery. Clinical and laboratory indices were analyzed before and 1 and 2 days after surgery. Results. The study has revealed that renal reperfusion lesion plays a prominent role in the development of renal failure in cancer patients after elimination of longstanding urinary tract obstruction, which should be borne in mind when preparing patients for surgery and managing them in the postoperative period, namely, to include membrane-stabilizers, antioxidants, and detoxicant therapy.
Highlights
Цель исследования — определить роль реперфузионного поражения почек в развитии почечной недостаточности у онкологических больных после устранения длительно формирующейся окклюзии мочевых путей
The study covered 26 patients in whom cancer disease was complicated by the development of urinary tract obstruction with evolving renal failure
The time course of changes in microcirculation, gas exchange, oxidative antioxidative balance, and renal function were investigated to study the mechanisms respon sible for the development of renal failure after surgery
Summary
Цель исследования — определить роль реперфузионного поражения почек в развитии почечной недостаточности у онкологических больных после устранения длительно формирующейся окклюзии мочевых путей. Проведенные исследования выявили важную роль ре перфузионного поражения почек в развитии почечной недостаточности у онкологических больных после устране ния длительно формирующейся обструкции мочевых путей, что необходимо учитывать при подготовке больных к операции и ведению их в послеоперационном периоде — включение в терапию мембранстабилизирующих, антиок сидантных препаратов и дезинтоксикационного лечения. The study has revealed that renal reperfusion lesion plays a prominent role in the development of renal failure in cancer patients after elimination of longstanding urinary tract obstruction, which should be borne in mind when preparing patients for surgery and managing them in the postoperative period, name ly, to include membrane stabilizers, antioxidants, and detoxicant therapy.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
