Abstract
Background: Purple laver ((Porphyra dentate) is a popular edible seaweed in Asia. This study examined protective effects of extract from purple laver extract (PLE) in diabetic mice.Methods: Content of carotenoids and anthocyanins in PLE was analyzed. PLE at 0.5 and 1% was supplied for 7 weeks.Results: PLE was rich in anthocyanins. PLE intake at 0.5 and 1% lowered plasma glucose level (P<0.05); only at 1% raised plasma insulin level, and decreased plasma triglyceride and total cholesterol levels (P<0.05). PLE treatments at 1% lowered hepatic triglyceride and total cholesterol (P<0.05); it reduced renal reactive oxygen species level (P<0.05); retained renal glutathione level, maintaining renal glutathione peroxidase and catalase activities (P<0.05).Conclusion: Porphyra dentate aqueous extract could attenuate diabetic progression via anti-oxidative and lipid lowering effects. This seaweed could be considered as potent healthy food, and used for personalized medicine.
Highlights
Diabetes is a common chronic disease in Taiwan and other countries
It is reported that purple laver contains iron and vitamin B12 [8, 9]
Our study found purple laver aqueous extract containing carotenoids and anthocyanins
Summary
Diabetes is a common chronic disease in Taiwan and other countries. Complications including nephropathy and atherosclerosis contribute to severity of this disease, as well as increase the mortality of patients. Diabetics are encouraged to consume more fresh vegetable and fruit in order to obtain phytochemicals like flavonoids, carotenoids and anthocyanins; most of these modify glucose homeostasis and afford anti-oxidative protection [4,5,6]. Its purple-red color seems to indicate the presence of carotenoids or anthocyanins It remains unknown whether this seaweed can provide preventive effect against diabetes. Our study examined protective effects and actions from Porphyra dentate against diabetic progression. This study examined protective effects of extract from purple laver extract (PLE) in diabetic mice. Conclusion: Porphyra dentate aqueous extract could attenuate diabetic progression via anti-oxidative and lipid lowering effects. This seaweed could be considered as potent healthy food, and used for personalized medicine
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