Renal Protective Effect of Quercetin on Cisplatin-Induced on Some Blood Parameters and Nephrotoxicity in Male Rats

Abstract

This work was carried out to investigate the possible protective effect of quercetin some blood parameters and nephrotoxicity in male rats treated with cisplatin. Cisplatin is an important chemotherapeutic agent useful in the treatment of several cancers such as tumors of the testis (including extragonadal germ cell tumors), ovarian cancer, small cell and non-small cell lung cancer, squamous cell carcinomas of the head and neck, and despite the availability of some newer and less toxic quercetin drugs. Eighteen blood samples were obtained from male rats which divided into three groups for each group (n = 6), the first group (control), the second group (Cisplatin) and third group (Cisplatin + Quercetin). There is a significant decrease (P <0.05) in Creatinine, urea and TNF-ά concentrations in second group compared with the control and third groups. Also, the result showed a significant increase Creatinine, urea and TNF-ά concentrations in second group compared with the control group. The results showed a significant increase (P≤0.05) in red blood cell count(RBC), packed cell volume (HCT), hemoglobin (Hb) and Platelet in second groups compared with the control and third groups, also it showed a significant decreasein third group compared with control group. Therefore, the present study is undertaken to investigate the possible some blood parameter and renal protective effect of quercetin in rats treated with cisplatin