Renal prostaglandin E 2 in nephrogenic diabetes insipidus: Effects of inhibition of prostaglandin synthesis by indomethacin

Abstract

uation o f this therapy in hospital did not obviate the need for peri toneal dialysis. Although abnormalities of coagulation have been demonstrated rarely in the HUS, 7 there is usually no evidence of ongoing disseminated intravascular coagulation in this disorder? Accordingly, there is little factual basis for anticoagulant therapy. As recommended by othersr we agree that a definite role for the use of inhibitors of platelet aggregation in the therapy of this disease must await more definitive studies clearly demonstrat ing that platelet consumption is a primary noxious event in the evolution of this syndrome.