Abstract
THE events taking place in the remaining kidney after unilateral nephrectomy have been investigated several times. RNA synthesis, as measured by the uptake of H3-cytidine, is increased within 1 h (ref. 1); protein synthesis is increased by 3 h (ref. 1); DNA synthesis increases by 24–48 h (refs. 2–5); an increase in mitotic activity has been variously reported to occur first at 24–48 h (refs. 5 and 6); and an increase in kidney weight is detectable 30–36 h after nephrectomy5. It is well established that this compensatory renal enlargement consists of both cellular hypertrophy and cellular hyperplasia1, although the number of nephron units apparently remains constant7.
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