Renal Manifestations in Children with Dengue Fever Hospitalized in Pediatric Intensive Care Unit

Abstract

To study the pattern of acute kidney injury in children with dengue infection hospitalized in an intensive care unit. This is a retrospective study from January 2019 through December 2019. Various renal manifestations of dengue were studied and compared between the severity of dengue fever. Three hundred nineteen children with dengue fever were hospitalized and 127 needed intensive care admission. Among the 127 patients, 26 (20.5%) children developed acute kidney injury (AKI). Children with severe dengue developed a higher number of AKI (n = 20; 28.6%), as compared to dengue with warning sign group (n = 6; 11.8%). Colloid infusion, inotropic support, ventilatory requirement and presence of secondary hemophagocytic lymphohistiocytosis were the risk factors for AKI. Nine children underwent dialysis. Among the AKI group, 23 recovered and 3 died and all three had multi organ dysfunction syndrome. It is essential to recognize the various renal manifestations of dengue AKI which is associated with increased mortality and morbidity.