Abstract
Spontaneously hypertensive rats (SHR), unilaterally nephrectomized, and treated with 30mg/kg streptozotocin (STZ), i.v., showed sustained high blood glucose (>200mg/dl) and pressure (>160mmHg) during 6 to 12-week-observation. Glomerular exudative and medial proliferative changes were seen in the kidney. Thus, an animal model of diabetic nephropathy with hypertension has been established. Moreover, hypertension was not observed in Wistar-Kyoto (WKY) or normal Wistar (WR) rats after STZ treatment. Existance of so-called STZ hypertension in the rat is suspicious.
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