Abstract
BackgroundAge-related changes in renal histomorphology are described, while the presence of glomerulonephritis in dogs with pyometra is controversial in current literature.MethodsDogs with pyometra were examined retrospectively for evidence of secondary renal damage and persisting renal disease through two retrospective studies. In Study 1, light microscopic lesions of renal tissue were graded and compared in nineteen dogs with pyometra and thirteen age-matched control bitches. In Study 2, forty-one owners of dogs with pyometra were interviewed approximately 8 years after surgery for evidence ofclinical signs of renal failure in order to document causes of death/euthanasia.ResultsInterstitial inflammation and tubular atrophy were more pronounced in dogs with pyometra than in the control animals. Glomerular lesions classified as glomerular sclerosis were present in both groups. No unequivocal light microscopic features of glomerulonephritis were observed in bitches in any of the groups.Two bitches severely proteinuric at the time of surgery had developed end stage renal disease within 3 years. In five of the bitches polyuria persisted after surgery. Most bitches did not show signs of kidney disease at the time of death/euthanasia.ConclusionTubulointerstitial inflammation was observed, but glomerular damage beyond age-related changes could not be demonstrated by light microscopy in the dogs with pyometra. However, severe proteinuria after surgery may predispose to development of renal failure.
Highlights
Age-related changes in renal histomorphology are described, while the presence of glomerulonephritis in dogs with pyometra is controversial in current literature
Severe proteinuria after surgery may predispose to development of renal failure
Proteinuria is the hallmark of glomerular disease
Summary
Age-related changes in renal histomorphology are described, while the presence of glomerulonephritis in dogs with pyometra is controversial in current literature. In both human [1] and veterinary nephrology [2,3]., proteinuria has been shown to contribute substantially to the development of end stage renal disease. Clinical intervention by drug therapy is indicated to protect renal function [4]. Polydipsia (PU/PD), proteinuria and azotemia are common features of canine pyometra [5,6,7,8,9,10]. Because polyuria/polydipsia usually disappear after treatment, the accompanying renal lesions are described as temporary. The renal pathology and long term clinical outcome in (page number not for citation purposes)
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