Renal Hücreli Karsinomlu Yaşlı Hastalarda Sağkalım Sonuçları: Tek Merkez Deneyimi

Abstract

Objective: The aim of the study was to investigate the survival outcomes in elderly patients with renal cell carcinoma (RCC) in our series. Materials and Methods: From January 2010 to June 2019, 174 patients with renal cell carcinoma who underwent surgery in our institution were analyzed. Age, gender, history, presentation, tumor size,tumor, node, metastasis (TNM) stage, histologic subtype and Fuhrman grade of the patients were recorded. Patients were divided into two groups with the cut off value 70 of age. Group 1 was defined as the patients below the 70 years of age, whereas, Group 2 was defined as the patients 70 years of age and older. Results: One hundred three patients were in Group 1 and 71 patients were in Group 2. Mean disease-specific survival(DSS) time was 140.3±6.7 months in Group 1, while it was 105.3±7.9 months in Group 2 (p=0.061). Mean overall survival time (OAS) was 132.0±7.5 months in Group 1 and 95.2±8.3 months in Group 2 (p=0.046). Actuarial estimated disease-specific survival at 5 years was 88.5% in Group 1and 78.1 % in Group 2 (p=0.061). Actuarial estimated overall survival at 5 years was 83.0% in Group 1 and 70.7 % in Group 2 (p=0.046). In multivariate Cox regression analysis, T stage and Fuhrman grade were independent prognostic factors for survival. Conclusion: Our study demonstrated that there was no statistically significant difference in disease-specific survival rates between elderly patients with RCC, those compared with younger ones. Our findings recommend that surgery may be an option for older patients with RCC to avoid the potential hazard.