Abstract
The influence of 2 diuretics (D) on renal handling of uric acid (UA) was evaluated. 8 normal male volunteers (age : 32.5 ± 4.6, BW : 68 ± 8 kg, H : 175 ± 6 cm) received in random order placebo (P), methyclothiazide (MCT, 2 mg) alone or with triamterene (75 mg, MCT + T) for 4 days. Urine (u) was collected every 12 hours and blood (b) was drawn at days 1 and 5, for measurement of : b UA (micromol/1), excreted (u UA) and filtered (f UA) UA (micromol/min) and fractional clearance (f Cl UA) D increased (p <.05) b UA and f UA (40.78 for P, 56.92 for MCT, 50.06 for MCT + T) ; u UA varied not significantly (ns) and nycthemeral variation in u UA is maintened. In P, u UA = 1.88 + 0.04 f UA, r = .60, p < .001 , the same correlation is observed with MCT + T, but u UA is too low for f UA in MCT. In P, f Cl UA (.099 ± .027) is negatively correlated with b UA (312 ± 48) = − .007 + 30.27/b UA, r = .69, p < .001 ; in MCT + T f Cl UA is ns decreased (.084 ± .017) but normally correlated with b UA (366 ± 61) ; in MCT f C1 UA is further decreased (.074 ± .021, p < .01 vs P) despite similar increases in b UA (394 ± 55),hematocrit, proteins, renin activity, aldosteronemia and higher cumulative sodium excretion in MCT + T than in MCT. Conclusion : There is ns tendancy for MCT + T to lessen MCT induced changes in renal handling of UA, together with higher natriuretic activity.
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