Renal handling of calcium in the early newborn period

Abstract

Urinary calcium excretion was studied in two matched groups of 28 clinically-well preterm and fullterm infants between 24 and 48 hours of life. In the developmental period from 28 to 40 weeks gestation, urinary calcium excretion was positively correlated to the gestational age (r = 0.583, P less than 0.01), serum calcium levels (r = 0.512, P less than 0.01), the rate of glomerular filtration (r = 0.715, P less than 0.001), and urinary cyclic AMP excretion (r = 0.717, P less than 0.001). Urinary calcium excretion was independent of sodium and calcium intake, and urinary sodium and phosphate excretion. The mean fractional total calcium excretion and fractional ionized calcium excretion in babies less than or equal to 32 weeks was less than 1.0%, compared to greater than 2.5% for sodium. Serum calcium levels were positively correlated with gestational age (r = 0.803, P less than 0.001), and serum phosphate levels (r = 0.85, P less than 0.001). Whole blood ionized calcium levels were positively correlated to gestational age (r = 0.625, P less than 0.001), and serum total calcium levels (r = 0.440, P less than 0.05). The newborn kidney in babies less than or equal to 32 weeks gestation, did not have impaired conservation of calcium as for sodium; and neither sodium nor calcium intake appeared to affect urinary calcium excretion in the well newborn infant. Probably neither excess excretion of calcium nor serum phosphate levels contribute to early neonatal hypocalcemia.