Abstract
Renal tubular reabsorption of amylase was demonstrated in the rat by the use of the stop-flow technique. The sequential pattern of amylase following urinary stasis was depressed around the distal portion of the nephron, suggesting that the enzyme might be transported at a more distal portion compared with the site of paraaminohippurate transport. The ratio of urinary amylase to serum amylase ( U P ratio ) of less than 0.2 indicated that the reabsorption of the enzyme occurred against its concentration gradient. The present results yield a hypothesis that decreased tubular clearance of amylase may be an important factor for interpreting increased clearance of the enzyme during pancreatitis.
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