RENAL FUNCTIONAL STATE IN ESSENTIAL HYPERTENSIVE PATIENTS SUFFERING FROM TYPE 2 DIABETES WITH OR WITHOUT ATRIAL FIBRILLATION: PP.17.165

Abstract

Objective: To compare renal functional state in essential hypertensive patients having high risk type 2 diabetes mellitus (DM) with and without atrial fibrillation (AF). Methods and Design: In a result of initial analysis of 1192 high risk hypertensive (1st-2nd level of blood pressure increase (ESC, 2007)) patient's cards there were chosen 296 ones. Data are shown as means ± standard deviation of the mean. The patients, divided into 3 groups, were adjusted by gender, age, body mass index. 1st group – 92 persons with DM in combination with AF (47 males and 45 females, mean age 66 ± 8 y). 2nd group – 110 subjects with DM but without AF (55 males and 55 females, mean age 63 ± 8 y). 3rd group – 100 subjects with nonvalvular and nonthyreotoxic AF (52 males and 48 females, mean age 67,5 ± 8 y). Office baseline pulse blood pressure levels were 56 ± 16, 57 ± 18, 68 ± 20 mmHg respectively (1st vs 3rd groups p < 0,05; 2nd vs 3rd groups p < 0,05). There were studied a number of laboratory parameters: serum levels of creatinin (fmol/L), glomerular filtration rate on MDRD (GFR, ml/min/1.73 m2)), serum levels of potassium (mmol/L). Results: Percentage of that subjects who had criteria of chronic kidneys disease (GFR<60 ml/min/1.73 m2) was the same in the groups (53,4% vs 50,9% vs 47,9%; p > 0,05). Average GFR (65,7 ± 15,9; 66,7 ± 23,7; 72 ± 17,3), levels of creatinin (82,9 ± 24; 82,5 ± 18,8; 86,7 ± 25,7) and potassium (4,69 ± 0,55; 4,78 ± 0,52; 4,72 ± 0,45) did not differ significantly in the groups (p > 0,05). Conclusions: Researched by us hypertensive high risk type 2 diabetes mellitus patients with and without atrial fibrillation had the same parameters of renal functional state.