Renal function in two-kidney deoxycorticosterone acetate-hypertensive Yucatan miniature swine.

Abstract

AbstractTo determine renal function in two-kidney deoxycorticosterone acetate (DOCA)-treated Yucatan miniature swine, eight animals were implanted with DOCA-treated silicone strips. After 3–4 weeks, mean arterial pressure (MAP) increased by approximately 32% to 148 ± 4 mm Hg. Eight sham-implanted control swine were also studied. Pentobarbital anesthesia decreased MAP in DOCA animals to 116 ± 6 mm Hg, a value similar to that seen in the anesthetized controls (112 ± 4 mm Hg). Renal blood flow and glomerular filtration rates were significantly higher in control as compared to DOCA animals (P < 0.05). Radioactive microsphere distribution to the outer cortex was also significantly decreased and inner cortical blood flow was significantly higher in the DOCA-treated animals (P < 0.05). Urine flow rates were similar between the two groups, whereas sodium excretion was lower and potassium excretion was higher in the DOCA-treated animals. These data indicate that DOCA-hypertensive Yucatan miniature swine appear to ...