Abstract
Pregnancy affects the physiology of the pregnant woman, particularly the cardiovascular, renal and endocrine systems. In this study 120 adult women were divided into four groups of two non-pregnant and two pregnant women consisting of 30 women each. The non-pregnant were the nulliparous (control of 30 women) and grand multiparous women who had stopped gestation (GMS) for at least 2 years (30 women). The sixty pregnant women were divided into primigravidal (PG) of 30 women and gradmultiparous (GMP) of 30 women also. Glomerular filtration rate (GFR) was measured in these women using endogenous creatinine clearance (Ccr). The pregnant women were studied during their 1st, 2nd and 3rd trimester. The results show that control, PG, GMP and GMS groups had a mean GFR of 99.20 + 2.16, 115 + 3.41, 113 + 3.08 and 114 + 3.20 respectively. The mean GFR increased significantly (P Key Words: Pregnancy, gestation, nulliparous, primigravida, grandmultiparous, GFR (glomerular filtration rate), creatinine clearance. Nig. J Health and Biomed. Sciences Vol.2(2) 2003: 73-77
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