Abstract
There is a significant association between salt intake and high blood pressure that could be related to alterations in the ability of the kidneys to excrete sodium chloride. Preliminary data from our group showed an increase in blood pressure of 11% in rats with salt added to the drinking water (1%) during 10 days; therefore the aim of this study was to evaluate renal function changes induced in rats by high salt intake. Male Wistar rats (n=5/group) were divided in Control group (CG) and Salt group (SG), (1%, drinking water, 10 days). Isolated kidneys were perfused with Krebs‐Henseleit solution containing 6% (g weight) of previously dialyzed bovine serum albumin. Glomerular filtration rate (GFR), renal vascular resistance (RVR), urinary flow (UF), fractional sodium and potassium tubular absortion (%TNa+ and %TK+) and Clearance osmolar (Cosm) were determined during 120 min. In SG group we observed an increased in GFR, (SG: 1.1 ± 0.04 vs CG: 0.4±0.01 mL/g/min), associated with markedly augments in UF (SG: 0.2±0.05 vs CG: 0.1±0.01 mL/g/min). There were no changes in RVR (SG: 6±1 vs CG: 4±0.4 mmHg/mL/g/min). The %TNa+ (SG: 73±3 vs CG: 74±6, %) was similar between the groups. However, salt intake increased the %TK+ (SG: 75±5 vs CG: 58±4 %) and Cosm (SG: 0.2±0.06 vs CG: 0.1±0.01, mL/g/min). These findings demonstrate that renal alterations observed herein are not related to blood pressure increased.
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