Abstract
CONTENTS PAGE Introduction 117 A cellular model for Clsecretion in renal epithelial cells 118 The apical Clconductance(s) 120 Claccumulation at the basolateral membrane 120 Activation of basolateral K+ channels, augmentation of Clsecretion 122 Evidence for Clsecretion in intact mammalian renal tubules 124 Sites along the nephron 124 Apical Clchannels (conductance) in renal cells 124 Is Claccumulated above its electrochemical equilibrium level in renal epithelial cells? 125 Evidence from cystic fibrosis 126 The basic defect in cystic fibrosis 126 The cystic fibrosis gene product is abundantly expressed within human kidney 127 Renal defects associated with cystic fibrosis patients 130 Conclusion 131 References 131
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