Abstract
Several mammalian renal Na-dependent transport systems for inorganic phosphate have recently been identified using oocytes Xenopus laevis as an expression system. Expression of cloned transporters in oocytes resulted in Na/Pi cotransport activity with kinetic properties characteristic for proximal tubular apical Na/Pi cotransport. Sequence comparison suggests that renal Na/Pi cotransport systems cloned so far may belong to two different types/families of Na/Pi cotransporters. Localization of corresponding mRNAs and proteins revealed that both types of Na/Pi cotransporter systems are expressed in the apical membrane of proximal tubular cells. Evidence was obtained that one type of cloned renal Na/Pi cotransporter plays an important role in the physiological and pathophysiological regulation of renal Pi reabsorption.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
