Abstract
The effects of a synthetic α-human atrial natriuretic polypeptide (α-hANP) on renal hemodynamics and urine formation were investigated in anesthetized dogs. Intrarenal arterial infusion of the peptide (1.0 μg/min) increased renal blood flow, glomerular filtration rate and urine flow with no change in systemic blood pressure. A lower dose of α-hANP (0.2 μg/min) produced a significant diuresis and natriuses, while renal hemodynamics remained unchaged. The urinary excretion of Na, Cl and Ca was increased in proportion to the urine flow. We propose that α-hANP inhibits tubular reabsorption of electrolytes, and in higher dose produces renal vasodilation.
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