Renal Dysfunction Worsened by Superimposition of IgA Glomerulonephritis in a Patient with Overt Diabetic Nephropathy

Abstract

The combination of glomerulonephritis and diabetes nephropathy has been reported to occur in 1.8–22% of biopsy-proven diabetic nephropathy cases [1–6]. In these reports, however, the onset of glomerulonephritis during the course of diabetic nephropathy was not described in detail, and how the superimposition of glomerulonephritis affected renal function, particularly at the advanced stage of diabetic nephropathy. We recently encountered a patient, in whom the onset of IgA glomerulonephritis was detected clinically during the advanced stage of overt diabetic nephropathy. In this case, the onset of glomerulonephritis significantly increased the progressive deterioration of renal function.