Abstract
A woman with toxic epidermal necrolysis and severe renal involvement is described. Serial renal biopsies were compatible with membranoproliferative glomerulonephritis. The pathophysiology and renal manifestations of toxic epidermal necrolysis are reviewed, and several previously unreported cases of toxic epidermal necrolysis with renal involvement are discussed. In several cases, changes were consistent with membranous or membranoproliferative glomerulonephritis, lending support to the concept of toxic epidermal necrolysis as an immunologic disease.
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