Renal Denervation in Kidney Transplant Patients.

Abstract

Objectives: This study investigates the effect of renal denervation in kidney transplant patients with hypertension refractory to treatment according to the following definition: patients with blood pressure (BP) 140/90 mm Hg with a minimum of three drugs including a diuretic (JNC VII and ESH guidelines / ESC), in adequate doses and dismissing the causes of hypertension after renal transplantation and confirmed through ambulatory blood pressure in 24 hours. Background:Hypertension in patients after renal transplantation is a cause of renal graft loss, and must be treated renal denervation is proposed as an alternative to invasive antihypertensive therapy that has not been applied in these patients. Methods: We studied 8 patients with renal transplantation and hypertension resistant to treatment of moderate to severe hypertension and confirmed by ambulatory blood pressure within 24 hours of diagnosis, renal denervation was performed using renal denervation “simplicity” catheter (Medtronic Inc, C.A.). Results: Patientschangingfrom first tosixth monthfoundstatisticallysignificant decreasein blood pressureanddecrease inthe numberof antihypertensive drugs. Conclusion: Ourdata showthat applying therenaldenervationimprovementin blood pressurewithin 24 hoursofrenaltransplant patients withhypertensionand is offered asan alternative treatmentto avoidgraft damageandothercomplicationsof hypertension.