Renal denervation improves 24-hour central and peripheral blood pressures, arterial stiffness, and peripheral resistance.

Abstract

Ambulatory blood pressure (BP) and central BP are better predictors for overall cardiovascular risk and mortality than brachial BP. Renal denervation (RDN) has been shown to reduce office brachial and central BP as well as brachial ambulatory BP, but data on central ambulatory BP are limited. Patients (N=94) with treatment resistant hypertension (TRH) who underwent RDN were included. Ambulatory BP, including central pressures, hemodynamics, and arterial stiffness were measured at baseline and 3, 6, 12months after RDN by an oscillometric device (MobiloGraph™ ). At 3, 6, and 12-month follow-ups, brachial ambulatory BP was reduced (P for all <.001). Consistently, central ambulatory BP was reduced (P for all <.001). Ambulatory assessed averaged daytime pulse wave velocity improved after RDN (P<.05). Total vascular resistance decreased (P for all <.01). In patients with TRH, RDN improves brachial and central ambulatory BP, arterial stiffness, and total vascular resistance, indicating an improvement of cardiovascular outcome.