Abstract
Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.
Highlights
Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major
Comparison of some renal function markers between patients with βTM and healthy control subjects showed that calciuria had no significant difference (P = 0.8), whereas hyperfiltration (GFR; P = 0.00 by MDRD and P = 0.001 by correlation with age (CG)) and proteinuria (P < 0.05) (Table 1) were common findings
Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the control group
Summary
Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration. Thalassemia is the most common single gene disorder around the world This disease as a type of chronic, microcytic and inherited anemia, is associated with defects in hemoglobin synthesis and reduced life span of red blood cells [1]. Some of the renal complications in patients with βTM include increased renal plasma flow, failure of urine concentration, renal tubular acidosis, renal tubulopathy such as hypercalciuria and proteinuria [3,4,5,9]
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