Abstract
IntroductionMetastatic neoplasms to the thyroid gland are rare in clinical practice. Clear cell renal carcinoma is the most frequent site of origin of thyroid metastases and represents 12 to 34% of all secondary thyroid tumors. Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are exceedingly rare. We report a case of clear cell renal carcinoma metastatic to a follicular adenoma. This is the tenth case of renal cell carcinoma metastasis to thyroid tumor reported in the literature.Case presentationA 62-year-old Caucasian woman with a history of clear cell renal carcinoma was admitted to our institution for multinodular goiter. A histological examination after total thyroidectomy revealed clear cell renal carcinoma metastasis to a thyroid follicular adenoma.ConclusionsPreoperative diagnosis of secondary thyroid neoplasm is difficult to achieve. The diagnosis of metastatic disease should be taken into account if patients have a history of clear cell renal carcinoma or if there is a multifocal growth pattern and clear cell appearance of the cytoplasm.
Highlights
Metastatic neoplasms to the thyroid gland are rare in clinical practice
The diagnosis of metastatic disease should be taken into account if patients have a history of clear cell renal carcinoma or if there is a multifocal growth pattern and clear cell appearance of the cytoplasm
Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are extremely rare [2]; to the best of our knowledge, only nine cases of renal cell carcinoma metastasis to thyroid tumor have been previously reported in the literature (Table 1) [3,4,5,6,7]
Summary
Thyroid metastasis should be considered in patients with a thyroid nodule and positive history for CCRC. Calò PG, Pisano G, Medas F, Tatti A, Pittau MR, Demontis R, Favoriti P, Nicolosi A: Intraoperative recurrent laryngeal nerve monitoring in thyroid surgery: is it really useful? Doi:10.1186/1752-1947-7-265 Cite this article as: Medas et al.: Renal cell carcinoma metastasis to thyroid tumor: a case report and review of the literature. GP participated in the design of the study and helped to draft the manuscript. Author details 1Department of Surgical Sciences, University of Cagliari, Cagliari, Italy. Author details 1Department of Surgical Sciences, University of Cagliari, Cagliari, Italy. 2Department of Cytomorphology, University of Cagliari, Cagliari, Italy. 3University of Texas, Galveston, Texas, USA
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