Renal cell carcinoma in acquired cystic kidney disease: Volume growth rate determined by helical computed tomography

Abstract

The aim of this study is to determine the growth rate and behavior of renal cell carcinoma in chronic hemodialysis patients with acquired cystic kidney disease (ACKD). Renal cell carcinomas in 17 hemodialysis patients (mean age, 52 ± 11 years; mean hemodialysis duration, 7.2 ± 3.3 years) with ACKD were examined with helical computed tomography (CT) for 0.5 to 6.0 years (mean, 2.1 ± 1.9 years). The 17 renal cell carcinomas were histologically proven and graded after nephrectomy (16 patients) or autopsy (1 patient). Tumor volume was estimated by counting the number of pixels in the tumor and a 1-cm2 area on helical computed tomographic scan using a personal computer. Estimated volume growth rates and doubling times of the carcinoma were correlated with histological grades. Fifteen of the 17 neoplasms (88%) were less than 3 cm in diameter at initial CT. The overall volume growth rate was 0.07 to 17.34 cm3/y (mean, 4.14 ± 5.66 cm3/y), and the estimated volume-doubling time was 0.08 to 23.31 years (mean, 5.09 ± 6.99 years). The mean growth rate of the 3 grade 3 carcinomas was 6.01 ± 4.50 cm3/y (range, 0.88 to 9.28 cm3/y), which was significantly greater than that of the 9 grade 1 carcinomas (0.40 ± 0.40 cm3/y; range, 0.09 to 1.37 cm3/y) or the 5 grade 2 tumors (0.79 ± 0.74 cm3/y; range, 0.12 to 2.00 cm3/y). Eleven of the 17 carcinomas (65%) had more than a 1-year volume-doubling time. The 3 grade 3 neoplasms and 1 of the grade 2 lesions had less than a 0.5-year doubling time.