Abstract
The distribution pattern of renal cell carcinoma (RCC) histological subtypes according to age, gender and tumor size has not been well illustrated in RCC patients living in fast-developing regions of China. We recruited 2941 patients with clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (PCC) or chromophobe from two hospitals in coastal China (2004−2012) consecutively and draw 538 American Chinese RCC patients’ data with time matched from the Surveillance, Epidemiology, and End Results database. We found that compared with ccRCC patients, chromophobe patients were more likely to be female (OR: 2.538, 95% CI: 1.923−3.350), younger (OR for 51−60 years old: 0.686; OR for over 60 years old: 0.478; reference: age < 50) and to have a larger maximal diameter (Dmax) (OR for Dmax > 7 cm: 1.883; reference: Dmax ≤ 4 cm). Besides, in comparison with coastal Chinese patients, American Chinese individuals had lower Fuhrman grades (P < 0.001) and had an onset age 10 years delay. In conclusion, we were the first to observe marked gender, age and tumor size differences in the proportional subtype distribution of RCCs in coastal Chinese patients, and also the first to compare coastal Chinese with American Chinese data.
Highlights
Renal cell carcinoma (RCC) is a deadly malignancy [1]
We found that compared with clear cell renal cell carcinoma (ccRCC) patients, chromophobe patients were more likely to be female (OR: 2.538, 95% confidence interval (CI): 1.923−3.350), younger (OR for 51−60 years old: 0.686; OR for over 60 years old: 0.478; reference: age < 50) and to have a larger maximal diameter (Dmax) (OR for Dmax > 7 cm: 1.883; reference: Dmax ≤ 4 cm)
In our coastal Chinese patient cohort, we found that ccRCC was more common in male patients, and the proportion of females with chromophobe was higher than males
Summary
RCC incidence has been shown to be associated with a country’s developing level [2]. There are several RCC histological subtypes that have distinct genetic and clinical features. The most commonly diagnosed subtypes are clear cell RCC (ccRCC), papillary RCC (PCC), and chromophobe [5]. These subtypes are associated with distinct molecular and genetic characteristics [6]. Recent studies suggest that the distribution of RCC histological subtypes is not equivalent in different racial groups [7, 8]. The distribution of RCC histological subtypes in Chinese patients, those from coastal areas, has not been well investigated previously
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
