Renal Biochemical Marker Changes in Restorative Activities of Curcuma longa on Sildenafil Induced Nephrotoxicity Among Male Albino Rats

Abstract

Background: Nephrotoxicity is the rapid deterioration of kidney function due to altered histoarchitecture and drug clearance characterized by increased levels of renal biochemical markers. Sildenafil is among the drugs postulated to cause nephrotoxicity if taken over a long period of time or as an overdose as it interferes with the kidney histoarchitecture. Curcuma longa is a traditional herbal plant which is used in diet, treatment of diabetes, dermatological conditions and renal diseases. Objective: The aim of this study was to evaluate renal biochemical marker changes in restorative activities of Curcuma longa on sildenafil induced nephrotoxicity. Methodology: A total of 25 male albino rats of species rattus norvegiccus were used in this experiment. 5 rats received water and feeds, 20 received 1µg/gmbwt Sildenafil for 15 days from these 5 rats were sacrificed four hours post last dose. The remaining 15 rats were treated with Curcuma longa at calculated doses. Animals were sacrificed in humane end points, blood collected through cardiac puncture stored in sample bottle and centrifuged to harvest serum. Results: It was observed that blood urea and creatinine levels in Sildenafil-induced nephrotoxicity group significantly increased as compared to negative control group and reduced significantly in medium and high dose Curcuma longa groups. Conclusion: Based on this study it can be concluded that medium and high dose Curcuma longa reduces blood urea and nitrogen and creatinine levels when used in the assessment of restorative effects of Curcuma longa on Sildenafil induced nephrotoxicity among male albino rats.