Abstract
Totally ischemic canine kidneys were protected during periods of normothermic in vivo exposure known to be lethal (two and three hours) by means of initial perfusion with cold hyperosmolar intracellular electrolyte solutions containing no additives. The solutions are believed to exert their protective effects by preventing the rapid and profound alterations of intracellular electrolytes and water that occur when a kidney is rendered ischemic. The method described herein does not rely upon continuous renal cooling or metabolic inhibition of the ischemic kidney and does not limit operative accessibility.
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