Renal Apparent Diffusion Coefficient Values in Patients with Obstructive Uropathy and High Values of Creatinine.

F Sonmezgoz,Ş Karasu,T O Kalaycı,A Karakeci

doi:10.5334/jbr-btr.854

Abstract

Purpose: Diffusion weighted magnetic resonance imaging (DW-MRI) of the kidneys provides noninvasive information on renal function in healthy volunteers, and it is feasible in severely ill patients. It may provide information on the degree of kidney dysfunction.The purpose of this study is to evaluate apparent diffusion coefficient (ADC) values using DW-MRI in patients with obstructive uropathy and elevated serum creatinine levels.Methods: Fifty patients with high serum creatinine levels and diagnoses of chronic urinary obstruction detected by ultrasonography were included in this study.DW-MRIs were obtained from 50 patients with hydronephrotic kidneys and 26 healthy volunteers using a 1.5T whole-body MR scanner.Results: ADC measurements of renal parenchyma in hydronephrotic kidneys were significantly lower compared to normal kidneys (p < 001).Conclusion: The measurement of ADC values has potential value in the evaluation of the functional status of hydronephrotic kidneys.

Highlights

Diffusion weighted magnetic resonance imaging (DW-MRI) of the kidneys provides noninvasive information on renal function in healthy volunteers, and it is feasible in severely ill patients
Urinary tract obstruction that causes hydronephrosis may lead to an increased pressure proximal to the obstruction, including the tubules and the renal interstitium, causing tubular dysfunction, a decrease in glomerular filtration rate (GFR) and increased serum creatinine levels
The purpose of this study is to evaluate the value of apparent diffusion coefficient (ADC) values from DW-MRI in patients with obstructive uropathy and elevated serum creatinine levels

Summary

Introduction

Diffusion weighted magnetic resonance imaging (DW-MRI) of the kidneys provides noninvasive information on renal function in healthy volunteers, and it is feasible in severely ill patients. It may provide information on the degree of kidney dysfunction. The purpose of this study is to evaluate apparent diffusion coefficient (ADC) values using DW-MRI in patients with obstructive uropathy and elevated serum creatinine levels. Individual renal function is usually evaluated by nuclear medicine techniques, which are considered as more reliable. Diffusion weighted magnetic resonance imaging (DW-MRI) of the kidneys gives non-invasive information on renal function in healthy volunteers, and it is feasible in severely ill patients. Quantitative data on the degree of renal dysfunction may be obtained [3]

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