Abstract
Titratable acidity/TA/and ammonium/NH4/of 67 neonates requiring IPPV or CPAP ventilation were daily determined from continuously collected urine for 92 hours. Irrespective of birth weight and maturity, an increase in TA and NH4 excretion by the 3 rd postnatal day was found in 57 infants. All these babies survived after 5 to 21 days of ventilation therapy. Eleven infants died on the 5 th to 12th postnatal day. In these cases the urinary TA and NH4 excretion gradually decreased, and the mean values on the 3rd and 4th day were significantly lower than those of the survivors.It is concluded that an early decline of TA and NH4 excretion predicts a rather poor prognosis of the ventilated neonate.
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