Abstract
Aluminum phosphide (AlP) self-poisoning leads to severe toxicity with a high mortality rate in developing coun- tries. No effective methods to treat se- vere AlP poisoning have been identified to date. It is surmised that toxic levels are blood concentrations above 1.067 mg%. In some instances of toxic exposure, char- coal hemoperfusion is an effective way to remove the poisonous substances from the circulation. However, it seems that ad- sorption of phosphine gas (PH 3 ), the toxic ingredient of AlP, by activated charcoal is not adequate and, therefore, it is unlikely that charcoal hemoperfusion would be ef- fective in treating AlP poisoning. Carbon nanotubes (CNTs) are appropriate for supporting metal nanoparticles. Cobalt (Co) and cerium (Ce) nanoparticles sup- ported on CNTs (CoCe-CNTs) have cat- alytic properties in the phosphine decom- position reaction. We hypothesize that the substitution of charcoal with CoCe alloy supported on CNTs in hemoperfusion car- tridges can be used to remove PH 3 from the plasma compartment to cure ALP poi- soning. We believe it is possible for this novel extracorporeal technique to become an efficient method for PH 3 removal, en- hancing the patient's chance of survival.
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